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Gold-Catalyzed Regio- and Stereoselective Alkenylation of Quinoline N -Oxides with Allenamides.

Mingduo LuYuanhong Liu
Published in: Organic letters (2024)
A gold-catalyzed cycloaddition/ring opening of allenamides with quinoline N -oxides has been developed, which provides C2-alkenylated quinolines with high E selectivity in moderate to high yields. It is noted that quinoline N -oxides with a C8 or C7 substituent are crucial for this catalytic reaction.
Keyphrases
  • molecular docking
  • room temperature
  • high intensity
  • molecular dynamics simulations
  • ionic liquid