The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.
Saleem Ullah Shahidnull ShabanaSteve HumphriesPublished in: Lipids in health and disease (2018)
The SNP rs10911021 was associated with CHD only in patients having diabetes, but the SNP was associated with total oxidative stress biomarkers MDA and GSH and GSSG levels. As the SNP rs10911021 showed significant association with oxidative stress parameters and these parameters should an increased oxidative stress in the CHD subjects, it can be concluded that the SNP may have contributed to increase the risk of heart diseases in the diabetic subjects by increasing the oxidative stress.
Keyphrases
- oxidative stress
- genome wide
- end stage renal disease
- dna damage
- ejection fraction
- type diabetes
- chronic kidney disease
- ischemia reperfusion injury
- newly diagnosed
- diabetic rats
- high density
- prognostic factors
- induced apoptosis
- cardiovascular disease
- gene expression
- patient reported outcomes
- cell proliferation
- atrial fibrillation
- heat shock
- weight loss
- adipose tissue
- heat stress