Targeting human epidermal growth factor receptor 2 enhances radiosensitivity and reduces the metastatic potential of Lewis lung carcinoma cells.
Yun TienChiao-Ling TsaiWei-Hsien HouYun ChiangFeng-Ming HsuYu-Chieh TsaiJason Chia-Hsien ChengPublished in: Radiation oncology (London, England) (2020)
Dual inhibition of radiation-activated EGFR and HER2 signaling by afatinib suppressed the proliferation and invasion of irradiated LLC cells. Increased radiosensitivity and decreased metastatic dissemination were observed by pharmacological or genetic HER2 inhibition in vivo. These findings indicate that HER2 plays a pivotal role in enhancing radioresistance and reducing metastatic potential of LLC cells.
Keyphrases
- epidermal growth factor receptor
- small cell lung cancer
- induced apoptosis
- squamous cell carcinoma
- tyrosine kinase
- advanced non small cell lung cancer
- cell cycle arrest
- endothelial cells
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- human health
- copy number
- radiation therapy
- cell proliferation
- dna damage
- climate change
- cancer therapy
- drug delivery
- induced pluripotent stem cells
- cancer stem cells