Molecular underpinnings of glandular tropism in metastatic clear cell renal cell carcinoma: therapeutic implications.
Eduard RousselLisa KingetAnnelies VerbiestBram BoeckxJessica Zucman-RossiGabrielle CouchyStefano CarusoMarcella BaldewijnsSteven JoniauHendrik Van PoppelDiether LambrechtsMaarten AlbersenBenoit BeuselinckPublished in: Acta oncologica (Stockholm, Sweden) (2021)
Patients with m-ccRCC who develop GM are molecularly characterized by heightened angiogenesis, translating into better prognosis and better outcomes on VEGFR-TKIs, but not IO. Based on these findings, VEGFR-TKIs should be included in the first-line treatment of m-ccRCC patients with GM.