Effect of TRPV4 activation in a rat model of detrusor underactivity induced by bilateral pelvic nerve crush injury.
Ei-Ichiro TakaokaMasahiro KurobeHiroki OkadaShun TakaiTakahisa SuzukiNobutaka ShimizuJoonbeom KwonHiroyuki NishiyamaNaoki YoshimuraChristopher J ChermanskyPublished in: Neurourology and urodynamics (2018)
Rats with bilateral PNC showed characteristics of DU, and this model seems appropriate for further evaluation of peripheral neurogenic mechanisms of DU. Also, TRPV4 receptors, the activation of which reduced bladder capacity and PVR, could be a target for DU treatment.