Gold Nanopeanuts as Prospective Support for Cisplatin in Glioblastoma Nano-Chemo-Radiotherapy.
Joanna DepciuchJustyna MiszczykAlexey MaximenkoPiotr M ZielinskiKamila RawojćAgnieszka PanekPaweł OlkoMagdalena Parlinska-WojtanPublished in: International journal of molecular sciences (2020)
Herein, we propose newly designed and synthesized gold nanopeanuts (Au NPes) as supports for cisplatin (cPt) immobilization, dedicated to combined glioblastoma nano-chemo-radiotherapy. Au NPes offer a large active surface, which can be used for drugs immobilization. Transmission electron microscopy (TEM) revealed that the size of the synthesized Au NPes along the longitudinal axis is ~60 nm, while along the transverse axis ~20 nm. Raman, thermogravimetric analysis (TGA) and differential scanning calorimetry (DCS) measurements showed, that the created nanosystem is stable up to a temperature of 110 °C. MTT assay revealed, that the highest cell mortality was observed for cell lines subjected to nano-chemo-radiotherapy (20-55%). Hence, Au NPes with immobilized cPt (cPt@AuNPes) are a promising nanosystem to improve the therapeutic efficiency of combined nano-chemo-radiotherapy.
Keyphrases
- locally advanced
- photodynamic therapy
- early stage
- electron microscopy
- rectal cancer
- sensitive detection
- radiation therapy
- squamous cell carcinoma
- single cell
- radiation induced
- reduced graphene oxide
- cancer therapy
- combination therapy
- high throughput
- type diabetes
- risk factors
- cell therapy
- coronary artery disease
- mesenchymal stem cells
- gold nanoparticles
- magnetic nanoparticles
- mass spectrometry
- drug delivery
- oxide nanoparticles