Xenotransplantation of tannic acid-encapsulated neonatal porcine islets decreases proinflammatory innate immune responses.

Jessie M Barra Veronika Kozlovskaya Jessica D Kepple Karen L Seeberger Purushothaman Kuppan Chad S Hunter Gregory S Korbutt Eugenia Kharlampieva Hubert M Tse

Published in: Xenotransplantation (2021)

Our data suggest that (PVPON/TA) encapsulation of NPIs is an effective strategy to decrease inflammatory innate immune signals involved in NPI xenograft responses through STAT1/6 modulation without compromising islet function.

Keyphrases

immune response
innate immune
electronic health record
dendritic cells
cell proliferation
oxidative stress
toll like receptor
big data
data analysis