The anti-inflammatory effect of 10-oxo-trans-11-octadecenoic acid (KetoC) on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide.

B SulijayaN TakahashiM YamadaM YokojiK SatoY Aoki-NonakaT NakajimaS KishinoJ OgawaKazuhisa Yamazaki

Published in: Journal of periodontal research (2018)

KetoC suppressed the proinflammatory cytokines TNFα, IL-6 and IL-1β via NF-κB p65, by binding to its receptor GPR120. KetoC is a promising candidate in future studies as a bioactive anti-inflammatory agent in treating periodontal disease.

Keyphrases

anti inflammatory
induced apoptosis
lps induced
signaling pathway
cell cycle arrest
rheumatoid arthritis
inflammatory response
pi k akt
oxidative stress
toll like receptor
current status
nuclear factor
case control
cell proliferation
binding protein