Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients.

Elena KhanovaRaymond WuWen WangRui YanYibu ChenSamuel W FrenchCristina LlorenteStephanie Q PanQihong YangYuchang LiRaul LazaroCharles AnsongRichard D SmithRamon BatallerTimothy MorganBernd SchnablHidekazu Tsukamoto

Published in: Hepatology (Baltimore, Md.) (2018)

These results implicate pyroptosis induced by the CASP11/4-GSDMD pathway in the pathogenesis of AH. (Hepatology 2018;67:1737-1753).

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
nlrp inflammasome
cell death
peritoneal dialysis
induced apoptosis
patient reported outcomes
oxidative stress
signaling pathway
insulin resistance
endoplasmic reticulum stress