High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients.
Robert R J Coebergh van den BraakAnieta M SieuwertsRaju KandimallaZarina S LalmahomedSandra I BrilAnne van GalenMarcel SmidKatharina BiermannJ Han J M van KriekenWigard P KloostermanJohn A FoekensAjay GoelJohn W M MartensJan N M IJzermansnull nullPublished in: PloS one (2017)
In our cohort, we discovered SYK(S) as a significant prognostic marker for HFS for patients with untreated LNN colon cancer. This association could however not be confirmed in two independent smaller cohorts, suggesting that further extensive validation is needed to confirm the prognostic value of SYK(S) expression in chemonaive LNN colon cancer.