Efficacy and safety of artemether-lumefantrine against uncomplicated falciparum malaria infection in Tanzania, 2022, a single arm clinical trial.

Jessica E LauryKefas MugittuDebora C KajegukaErasmus KamugishaDeus S IshengomaCeline I MandaraBilly NgasalaMercy G ChiduoMuhidin K MahendeJovin KitauMaimuna M AhmedSixbert I MkumbayeFilbert FrancisFrank ChackyMarian WarsameNaomi SerbantezChonge KitojoErik J ReavesDunstan R BishangaMarko BajicBilali I KabulaFlorida MuroReginald A Kavishe

Published in: The Journal of infectious diseases (2024)

Artemether-lumefantrine remains highly efficacious in three regions of Tanzania but the PCR-corrected efficacy in Pwani fell below the WHO-defined 90% threshold at which policy change is recommended. Implementing strategies to diversify ACTs to ensure effective case management in Tanzania is critical.

Keyphrases

clinical trial
healthcare
public health
phase ii
plasmodium falciparum
urinary tract infection