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[Supratentorial neuroepithelial tumor with PLAGL1 gene fusion - a new type of morphologically variable pediatric brain neoplasm defined by a distinct DNA methylation class. A case report and literature review].

D N KopachevMarina RyzhovaA N KislyakovE G ShaikhaevOlga ZheludkovaE V KumirovaS V MeshcheryakovP A VlasovA M ShkatovaZh B SemenovaArtem Gushcha
Published in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2024)
Methylation analysis in neurooncology is essential for unclear tumor morphology or divergence between histological and clinical data. In our case, this technique confirmed benign nature of tumor, and we preferred follow-up without unnecessary adjuvant treatment.
Keyphrases
  • dna methylation
  • genome wide
  • early stage
  • gene expression
  • big data
  • low grade
  • machine learning
  • copy number
  • brain injury
  • cerebral ischemia
  • data analysis