Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer's disease.
Alessandro Dario ConfetturaEleonora CuboniMohamed Rafeet AmmarShaobo JiaGuilherme M GomesPingAn YuanxiangRajeev RamanTingting LiKatarzyna M GrochowskaRobert AhrendsAnna KarpovaAlexander DityatevMichael R KreutzPublished in: Translational neurodegeneration (2022)
Collectively, the data suggest that neddylation and degradation of the insulin-receptor substrate is a nodal point that links high amyloid load, neuroinflammation, and synaptic insulin resistance to cognitive decline and impaired synaptic plasticity in high-risk aging.
Keyphrases
- cognitive decline
- insulin resistance
- type diabetes
- mild cognitive impairment
- lipopolysaccharide induced
- adipose tissue
- high fat diet
- traumatic brain injury
- lps induced
- metabolic syndrome
- polycystic ovary syndrome
- glycemic control
- skeletal muscle
- cognitive impairment
- prefrontal cortex
- high fat diet induced
- cerebral ischemia
- electronic health record
- binding protein
- amino acid
- lymph node
- inflammatory response
- big data
- neoadjuvant chemotherapy
- data analysis
- blood brain barrier