PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells.
Takahiro YamaguchiTeizo YoshimuraToshiaki OharaMasayoshi FujisawaGao TongAkihiro MatsukawaPublished in: Molecular biology reports (2021)
PolyI:C has a novel function to suppress the motility of LC cells undergoing EMT by targeting the phosphatidylinositol 3-kinase/Akt pathway partly via PTEN and may prevent or reduce the metastasis of LC cells.
Keyphrases
- induced apoptosis
- signaling pathway
- cell proliferation
- cell cycle arrest
- pi k akt
- protein kinase
- mass spectrometry
- simultaneous determination
- epithelial mesenchymal transition
- biofilm formation
- cell death
- high glucose
- high resolution
- drug induced
- liquid chromatography
- pseudomonas aeruginosa
- stress induced
- diabetic rats