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Is lack of goal-conflict-specific rhythmicity a biomarker for treatment resistance in generalised anxiety but not social anxiety or major depression?

Shabah M ShadliCarina J DoneganMuhammad Ss Bin Mohd FahmiBruce R RussellPaul GlueNeil McNaughton
Published in: Journal of psychopharmacology (Oxford, England) (2024)
Overall, these results suggest that GAD may occur in two forms: one resulting from excessive GCSR and so being drug sensitive, and the other resulting from some other mechanism and so being TR. In SAD and MDD groups, heightened GCSR could be a consequence rather than the cause, driven by mechanisms that are normally more sensitive to non-selective panicolytic antidepressants.
Keyphrases
  • major depressive disorder
  • sleep quality
  • healthcare
  • mental health
  • weight gain
  • bipolar disorder
  • body mass index
  • combination therapy
  • depressive symptoms
  • replacement therapy
  • smoking cessation