Dual Encapsulated Dacarbazine and Zinc Phthalocyanine Polymeric Nanoparticle for Photodynamic Therapy of Melanoma.
Sara Rhaissa Rezende do ReisEdward Helal-NetoAline Oliveira da Silva de BarrosSuyene Rocha PintoFilipe Leal PortilhoLuciana Betzler de Oliveira SiqueiraLuciana Magalhães Rebelo AlencarSi Amar DahoumaneFrank AlexisEduardo Ricci-JuniorPedro Filho Noronha SouzaPublished in: Pharmaceutical research (2021)
This work reports a robust nanoparticle formulation with the objective to leveraging the synergistic effects of chemo and photodynamic therapies to potentially suppressing the drug resistance and reducing side effects associated with Dacarbazine. The data corroborates that the dual encapsulated NPs showed better in-vitro efficacy when compared with the both compounds alone. The results support the need to have a dual modality NP formulation for melanoma therapy by combining chemotherapy and photodynamic therapy.
Keyphrases
- photodynamic therapy
- drug delivery
- cancer therapy
- fluorescence imaging
- electronic health record
- oxide nanoparticles
- squamous cell carcinoma
- iron oxide
- skin cancer
- emergency department
- stem cells
- locally advanced
- radiation therapy
- machine learning
- big data
- mesenchymal stem cells
- bone marrow
- rectal cancer
- basal cell carcinoma
- artificial intelligence