Base-peak assessment of levodopa response and detection of fluctuating patients in Parkinson's disease.
Roberta BonomoGiovanni MostileLoredana RacitiAlessandra NicolettiMario ZappiaPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)
The assessment of levodopa usual morning dose response through the base-peak evaluation represents an accurate method for detecting parkinsonian patients with motor fluctuations, and for defining the Minimal Important Difference (MID) in levodopa response suggesting the presence of motor fluctuations in PD patients demanding further therapeutic interventions.