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Triplet-Triplet Annihilation Upconversion-Based Photolysis: Applications in Photopharmacology.

Maxime KlimezakJuliane ChaudAnaïs BrionFrédéric BolzeBenoit FrischBéatrice HeurtaultAntoine KichlerAlexandre Specht
Published in: Advanced healthcare materials (2024)
The emerging field of photopharmacology is a promising chemobiological methodology for optical control of drug activities that could ultimately solve the off-target toxicity outside the disease location of many drugs for the treatment of a given pathology. The use of photolytic reactions looks very attractive for a light-activated drug release but requires to develop photolytic reactions sensitive to red or near-infrared light excitation for better tissue penetration. This review will present the concepts of triplet-triplet annihilation upconversion-based photolysis and their recent in vivo applications for light-induced drug delivery using photoactivatable nanoparticles.
Keyphrases
  • energy transfer
  • drug release
  • drug delivery
  • quantum dots
  • cancer therapy
  • photodynamic therapy
  • oxidative stress
  • high resolution
  • emergency department
  • high speed
  • combination therapy