Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors.

Jared M Odegard Ahmed A OthmanKai-Wen LinAdele Y WangJonathan NazarenoOh Kyu YoonJohn LingLatesh LadP Rod DunbarDung ThaiEdmond AngNicholas WaldronSanjeev Deva

Published in: Journal for immunotherapy of cancer (2024)

NCT04049617.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress