Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.

Zhiyu XiaYu-Ru SuPaneen PetersenLihong QiAndre E KimJane C FigueiredoYi LinHongmei NanLori C SakodaDemetrius AlbanesSonja I BerndtStéphane BézieauStephanie BienDaniel D BuchananGraham CaseyAndrew T ChanDavid V ContiDavid A DrewSteven J GallingerW James GaudermanGraham G GilesStephen B GruberMarc J GunterMichael HoffmeisterMark A JenkinsAmit D JoshiLoic Le MarchandJuan P LewingerLi LiNoralane M LindorVictor MorenoNeil MurphyRami NassirPolly A NewcombShuji OginoGad RennertMingyang SongXiaoliang WangAlicja WolkMichael O WoodsHermann BrennerEmily WhiteMartha L SlatteryEdward L GiovannucciJenny Chang-ClaudePaul D P PharoahLi HsuPeter T CampbellUlrike Peters

Published in: Cancer medicine (2020)

Aggregating G × E interactions and incorporating functional information, we discovered novel genes that may interact with BMI and diabetes on CRC risk.

Keyphrases

body mass index
genome wide
type diabetes
cardiovascular disease
dna methylation
glycemic control
weight gain
physical activity
gene expression
skeletal muscle
health information