Bromopyrrole Alkaloid Inhibitors of the Proteasome Isolated from a Dictyonella sp. Marine Sponge Collected at the Amazon River Mouth.
Renata T M P de SouzaVítor F FreireJuliana R GubianiRaquel O FerreiraDaniela B B TrivellaFernando C MoraesWladimir C ParadasLeonardo T SalgadoRenato C PereiraGilberto M Amado FilhoAntonio G FerreiraDavid E WilliamsRaymond J AndersenTadeusz F MolinskiRoberto G S BerlinckPublished in: Journal of natural products (2018)
The new pyrrole-imidazole and pyrrole-guanidine alkaloids 4-debromooroidin (1), 4-debromougibohlin (2), 5-debromougibohlin (3), and 5-bromopalau'amine (4), along with the known hymenidin (5) and (+)-monobromoisophakellin (6), have been isolated from a Dictyonella sp. marine sponge, collected at the Amazon River mouth. The bromine-substitution pattern observed for compounds 1, 2 and 4 is unusual among bromopyrrole alkaloids isolated from marine sponges. The 20S proteasome inhibitory activities of compounds 1-6 have been recorded, with 5-bromopalau'amine (4) being the most active in this series.
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