Buttressing Salicylaldehydes: A Multipurpose Directing Group for C(sp3 )-H Bond Activation.
Akira YadaWenqing LiaoYuta SatoMasahiro MurakamiPublished in: Angewandte Chemie (International ed. in English) (2016)
A palladium-catalyzed reaction of primary amines with iodoarenes produces γ-arylated primary amines. A bulky salicylaldehyde, which is marked as easily available, installable, removable, and recoverable, plays a key role in directing palladium to site-selectively activate the C-H bond located γ to the amino group.
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