Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway.

Xiao MaWenwen ZhangYuan ChenQichao HuZexin WangTao JiangYi ZengThomas Efferth

Published in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

PF exhibited a hepatoprotective effect in ANIT-induced CT, primarily by targeting GSDMD, thereby suppressing ANIT-induced pyroptosis and the subsequent release of inflammatory mediators.

Keyphrases

signaling pathway
high glucose
diabetic rats
drug induced
computed tomography
endothelial cells
pi k akt
contrast enhanced
image quality
stress induced
dual energy