Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue.

Megha MurthyGemma ShirebyYasuo MikiEmmanuelle ViréTammaryn LashleyThomas T WarnerJonathan MillConceicao Bettencourt

Published in: Neuropathology and applied neurobiology (2023)

Our findings show that oligodendrocyte proportions positively influence epigenetic age acceleration across brain regions and highlight the need to further investigate this in ageing and neurodegeneration.

Keyphrases

dna methylation
resting state
white matter
gene expression
functional connectivity
cerebral ischemia
multiple sclerosis
brain injury