Phenolics and triterpenoids from stem bark of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens and their cytotoxic activities.

Genus Calophyllum is well-known for its phenolic constituents, especially coumarins, which have shown to have a wide range of significant biological activities. In this study, four known phenolic constituents and two triterpenoids have been isolated from the stem bark of Calophyllum lanigerum . The compounds were two pyranochromanone acids are known as caloteysmannic acid ( 1 ), isocalolongic acid ( 2 ), a simple dihydroxyxanthone, namely euxanthone ( 3 ), one coumarin named calanone ( 4 ), and two common triterpenoids, friedelin ( 5 ), and stigmasterol ( 6 ). Chromanone acids were reported for the first time in this Calophyllum species. Cytotoxic evaluations were carried out on n -hexane extract (87.14 ± 2.04 µg/mL; 81.46 ± 2.42 µg/mL) followed by the chromanone acids ( 1 [79.96 ± 2.39 µM; 83.41 ± 3.39 µM] & 2 [57.88 ± 2.34; 53.04 ± 3.18 µM]) against two cancerous cell lines, MDA-MB-231 and MG-63 cell lines, respectively. The results showed that all tested samples exhibited moderate cytotoxicity.