Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male Mice.

Christian A UngerAhmed K AladhamiMarion C HopeWilliam E CothamKendall W NettlesDeborah J CleggKandy T VelázquezReilly T Enos

Published in: Endocrinology (2023)

Enhanced skeletal muscle aromatase activity in male mice induces weight loss, improves metabolic and inflammatory outcomes and mitigates the negative effects of a HFD. Additionally, our data demonstrate for the first time skeletal muscle E2 has anabolic effects on the musculoskeletal system.

Keyphrases

skeletal muscle
high fat diet
insulin resistance
weight loss
adipose tissue
metabolic syndrome
bariatric surgery
type diabetes
big data
roux en y gastric bypass
gastric bypass
machine learning
radiation therapy
deep learning