Reductive Cleavage of 4' H -Spiro[indole-3,5'-isoxazoles] En Route to 2-(1 H -Indol-3-yl)acetamides with Anticancer Activities.
Alexander V AksenovNikita K KirilovNikolai A ArutiunovDmitrii A AksenovIliya K KuzminovNicolai A AksenovDanielle N TurnerSnezna RogeljAlexander KornienkoMichael RubinPublished in: The Journal of organic chemistry (2022)
Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4' H -spiro[indole-3,5'-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1 H -Indol-3-yl)acetamides with antiproliferative properties.