A signalling cascade involving receptor-activated phospholipase A2, glycerophosphoinositol 4-phosphate, Shp1 and Src in the activation of cell motility.
Alessia VaroneStefania MariggiòManpreet PathejaVincenzo MaioneAntonio VarrialeMariangela VessichelliDaniela SpanoFabio FormigginiMatteo Lo MonteNadia BrancatiMaria FrucciPompea Del VecchioSabato D'AuriaAngela FlagielloClara IannuzziAlberto LuiniPiero PucciLucia BanciCarmen ValenteDaniela CordaPublished in: Cell communication and signaling : CCS (2019)
This study identifies a so-far undescribed mechanism of Shp1/Src modulation that promotes cell motility and that is dependent on the cPLA2 metabolite GroPIns4P. We show that GroPIns4P is required for EGF-induced fibroblast migration and that it is part of a cPLA2/GroPIns4P/Shp1/Src cascade that might have broad implications for studies of immune-inflammatory response and cancer.