Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.

Aline Umuhire Juru Zhengguo CaiAdina JanAmanda E Hargrove

Published in: Chemical communications (Cambridge, England) (2020)

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

Keyphrases

nucleic acid
drug discovery
mass spectrometry
molecularly imprinted
liquid chromatography