Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques.

Simon DeycmarBrendan J JohnsonKarina RayGeorge W SchaafDeclan Patrick RyanCassandra CullinBrandy L DozierBetsy FergusonBenjamin N BimberJohn D OlsonDavid L CaudellChristopher T WhitlowKiran Kumar Solingapuram SaiEmily C RomeroFrancois J VillingerArmando G BurgosHannah C AinsworthLance D MillerGregory A HawkinsJeff W ChouBruno GomesMichael HettichMaurizio CeppiJehad CharoJ Mark Cline

Published in: Journal of translational medicine (2024)

These data indicate that epigenetic silencing suppresses MLH1 transcription, induces the loss of MLH1 protein, abrogates mismatch repair, and drives genomic instability in naturally occurring CRC in rhesus macaques. We consider this spontaneous, uninduced CRC in immunocompetent, treatment-naïve rhesus macaques to be a uniquely informative model for human CRC.

Keyphrases

dna methylation
gene expression
endothelial cells
transcription factor
electronic health record
signaling pathway
late onset
induced pluripotent stem cells
copy number
big data
protein protein
machine learning
genome wide
small molecule
amino acid
binding protein
combination therapy
data analysis
deep learning