Cell interactome in sarcopenia during aging.
Laura González-BlancoManuel BermúdezJuan C Bermejo-MilloJosé Gutiérrez-RodríguezJuan J SolanoEduardo AntuñaIván Menéndez-ValleBeatriz CaballeroIgnacio Vega-NaredoYaiza Potes-OchoaAna Coto-MontesPublished in: Journal of cachexia, sarcopenia and muscle (2022)
Functionally dependent patients exhibited severe alterations in their cellular interactome at the muscle level. Cell apoptosis was caused by a decrease in successful protein synthesis, to which the cellular control systems did not respond adequately; autophagy was simultaneously blocked, the mitochondrion malfunctioned, and as the essential recovery mechanisms failed, these cells could not be replaced, resulting in the muscle being condemned to a loss of mass and functionality.
Keyphrases
- skeletal muscle
- end stage renal disease
- induced apoptosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- cell death
- peritoneal dialysis
- single cell
- endoplasmic reticulum stress
- prognostic factors
- oxidative stress
- early onset
- stem cells
- cell therapy
- mesenchymal stem cells
- patient reported outcomes
- community dwelling