A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Runjie SongShuoqian MaJiajia XuXin RenPeilan GuoHuijiao LiuPeng LiFan YinMei LiuQiang WangLei YuJiali LiuBinwei DuanNafis A RahmanSławomir WołczyńskiGuangming LiXiangdong LiPublished in: Molecular cancer (2023)
These results reveal that a novel circZKSCAN1-encoded peptide acts as a tumor suppressor on PI3K/AKT/mTOR pathway, and sensitizes HCC cells to sorafenib via ubiquitination of mTOR. These findings demonstrated that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.