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Oral ulcer treatment using human tonsil-derived mesenchymal stem cells encapsulated in trimethyl chitosan hydrogel: an animal model study.

Hyun Seok RyuCeline AbuevaAndrew PadalhinSo Young ParkSeung Hyeon YooHwee Hyon SeoPhil-Sang ChungSeung Hoon Woo
Published in: Stem cell research & therapy (2024)
This study has shown that the adhesion and viability of current stem cell therapies can be resolved by utilizing a hydrogel prepared with TMC and combining it with hTMSCs. The combined treatment can promote rapid healing of oral cavity wounds by enhancing anti-inflammatory effects and expediting wound healing. Therefore, hTMSC loaded in TMC hydrogel was the most effective wound-healing approach among all four treatment groups prolonging stem cell survival. However, further research is necessary to minimize the initial inflammatory response of biomaterials and assess the safety and long-term effects for potential clinical applications.
Keyphrases
  • wound healing
  • drug delivery
  • stem cells
  • inflammatory response
  • endothelial cells
  • escherichia coli
  • hyaluronic acid
  • cancer therapy
  • biofilm formation
  • loop mediated isothermal amplification