Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study.
Rebeca EriksenRachel GibsonMaria AresuAndy HeardQueenie ChanEvangelos EvangelouHe GaoPaul ElliottGary FrostPublished in: Endocrinology, diabetes & metabolism (2019)
The genetic effect on HbA1c was almost doubled in obese individuals, compared with those with a healthy weight, and independent of weight, there was a modest offset on HbA1c in high-genetic-risk individuals consuming a diet high in wholegrain. This supports the importance of a healthy diet high in wholegrains and along with maintaining a healthy weight in controlling HbA1c among high-genetic-risk groups.
Keyphrases
- weight loss
- physical activity
- type diabetes
- genome wide
- bariatric surgery
- body mass index
- copy number
- healthcare
- public health
- metabolic syndrome
- adipose tissue
- cardiovascular disease
- dna methylation
- mental health
- glycemic control
- gene expression
- body weight
- social media
- health information
- insulin resistance
- transcription factor
- quality improvement