A randomized clinical trial on the acute therapeutic effect of TRPA1 and TRPM8 agonists in patients with oropharyngeal dysphagia.

Noemi Tomsen Daniel Álvarez-Berdugo Laia Rofes Omar Ortega Fernández Viridiana Arreola Weslania Viviane Nascimento Alberto Martin Christopher Cabib Mireia Bolivar-Prados Lluís MundetColine LegrandPere ClavéStephanie Michlig

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

TRPA1 stimulation with CIN-Zn or CIT improves the swallow response which, in the case of CIN-Zn, is associated with a significant improvement in cortical activation and safety of swallow. These results provide the basis for the development of new active treatments for OD using TRPA1 agonists.

Keyphrases

heavy metals
liver failure
respiratory failure
drug induced
aortic dissection
risk assessment
hepatitis b virus
extracorporeal membrane oxygenation