Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes.

C M AlamJ S G SilvanderT O HeleniusDiana M Toivola

Published in: Acta physiologica (Oxford, England) (2018)

Partial K8 deficiency reduces β-cell stress tolerance and aggravates diabetes development in response to STZ, while there is no major susceptibility to HFD.

Keyphrases

diabetic rats
type diabetes
oxidative stress
high fat diet
cardiovascular disease
glycemic control
high glucose
cell therapy
adipose tissue
stem cells
stress induced
drug induced
bone marrow
skeletal muscle
wild type