Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase.

Yue GuoDonghao GuoShaoting ZhangYuan ZhangXiaoyan HeXiaohua JiangAndrew Man-Lok ChanLin ZouJianmin SunHui Zhao

Published in: Cell & bioscience (2022)

In this study, we investigated the oncogenic roles of PI3K isoforms in neuroblastoma. Our data shed light on PI3K isoform p110α in the tumorigenesis of neuroblastoma, and strongly suggest the p110α inhibitors as potential drugs in treating neuroblastoma.

Keyphrases

tyrosine kinase
diffuse large b cell lymphoma
signaling pathway
transcription factor
big data
mass spectrometry
risk assessment
atomic force microscopy
artificial intelligence