Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia.

Boyan WangYi WangHainan ChenSenyu YaoXiaofan LaiYuan QiuJianye CaiYinong HuangXiaoyue WeiYuanjun GuanTao WangJiancheng WangAndy Peng Xiang

Published in: Stem cell research & therapy (2021)

This study investigated the role of TGFβ released by bone remodeling in the progression of cancer-related anemia and revealed a potential therapeutic approach for relieving defects in hematopoiesis.

Keyphrases

hematopoietic stem cell
transforming growth factor
chronic kidney disease
iron deficiency
epithelial mesenchymal transition
atomic force microscopy
high resolution