Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-13 C]pyruvate magnetic resonance spectroscopy.
Rasmus Stilling TougaardChristoffer LaustsenThomas Ravn LassenHaiyun QiJakob Lykke LindhardtMarie SchroederNichlas Riise JespersenEsben Søvsø Szocska HansenSteffen RinggaardHans Erik BøtkerWon Yong KimHans Stødkilde-JørgensenHenrik WiggersPublished in: Magnetic resonance in medicine (2021)
In a rat model of moderate heart failure, medical treatment improved function, but did not on average influence [1-13 C]pyruvate flux as measured by MRS; however, responders to heart failure medication had reduced capacity for carbohydrate metabolism.