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Impaired mitochondrial respiration in upper compared to lower body differentiated human adipocytes and adipose tissue.

Ioannis G LempesisNicole HoebersYvonne EssersJohan W E JockenLudwig J DuboisEllen E BlaakKonstantinos N ManolopoulosGijs H Goossens
Published in: The Journal of clinical endocrinology and metabolism (2024)
The present findings demonstrate that in vitro mitochondrial respiration and in vivo oxygen fractional extraction are lower in upper compared to lower body differentiated hMADS and AT, respectively, in postmenopausal women.
Keyphrases
  • postmenopausal women
  • adipose tissue
  • bone mineral density
  • oxidative stress
  • endothelial cells
  • insulin resistance
  • high fat diet
  • metabolic syndrome
  • induced pluripotent stem cells
  • body composition