The incidence of brainstem toxicity following high-dose conformal proton therapy for adult skull-base malignancies.

Adam L Holtzman Michael S RutenbergAlexandra N De LeoDinesh RaoJeet PatelChristopher G MorrisDaniel J Indelicato William M Mendenhall

Published in: Acta oncologica (Stockholm, Sweden) (2022)

In delivering curative-intent radiotherapy for skull-base chordoma and chondrosarcoma in adults, small volumes of the brainstem can safely receive at least 64 GyRBE with minimal risk of serious brainstem injury.

Keyphrases

high dose
early stage
low dose
risk factors
radiation therapy
oxidative stress
locally advanced
rectal cancer
radiation induced