Application of Nanotechnology in Thrombus Therapy.

A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow and causing clinical symptoms. Thrombosis is associated with many life-threatening cardiovascular diseases. However, current clinical therapeutic technologies still have many problems in targeting, enrichment, penetration and safety to meet the thrombosis treatment needs. Therefore, researchers have devoted themselves to developing nano-systems loaded with antithrombotic drugs to address this paradox in recent years. Herein, we first review the existing thrombosis treatment technologies and outline their advantages and disadvantages based on a brief discussion of thrombosis's definition and formation mechanism. Furthermore, the need and application cases for introducing nanotechnology are discussed, focusing on thrombus-specific targeted ligand modification technology and microenvironment-triggered responsive drug release technology. Then, nanomaterials that can be used to design antithrombotic nanotherapeutic systems are summarized. Moreover, we also introduced a variety of drug delivery technologies driven by nanomotors in thrombosis therapy. Finally, a prospective discussion on the future development of nanotechnology for thrombosis therapy is highlighted. This article is protected by copyright. All rights reserved.