Population Pharmacokinetics of Levofloxacin and Moxifloxacin, and the Probability of Target Attainment in Ethiopian Patients with Multidrug-Resistant Tuberculosis.
Temesgen SidamoPrakruti S RaoEleni AklilluWorkineh ShibeshiYumi ParkYong-Soon ChoJae-Gook ShinScott K HeysellStellah G MpagamaEphrem EngidaworkPublished in: Infection and drug resistance (2022)
The standard doses of LFX and MXF may not provide adequate drug exposure. PopPK of LFX is more predictable for maximum mycobacterial kill, whereas MXF's resistance prevention target increases with dose. Cr and BMI are likely important covariates for dose optimization in Ethiopian patients.
Keyphrases
- multidrug resistant
- end stage renal disease
- mycobacterium tuberculosis
- ejection fraction
- chronic kidney disease
- newly diagnosed
- body mass index
- peritoneal dialysis
- prognostic factors
- emergency department
- escherichia coli
- gram negative
- weight loss
- human immunodeficiency virus
- patient reported
- pseudomonas aeruginosa
- klebsiella pneumoniae
- hiv infected