Mapping the deformability of natural and designed cellulosomes in solution.

Jonathan DorivalSarah MoraïsAurore LabourelBartosz RozyckiPierre-Andre CazadeJérôme DabinEva Setter-LamedItzhak MizrahiDamien ThompsonAurélien ThureauEdward A BayerMirjam Czjzek

Published in: Biotechnology for biofuels and bioproducts (2022)

Our data quantifies variability of form and compactness of cellulosomal components in solution and confirms that this native plasticity may well be related to speciation with respect to the substrate that is targeted. By showing that scaffoldins or components display enhanced compactness compared to the free objects, we provide new routes to rationally enhance their stability and performance in their environment of action.

Keyphrases

high resolution
electronic health record
cancer therapy
big data
amino acid
data analysis
mass spectrometry
drug induced
structural basis