Missing data strategies for the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in Alliance A091105 and COMET-2.

Gina L MazzaMolly M PetersenBrenda GinosBlake T LanglaisNarre HeonMrinal M GounderMichelle R MahoneyAlexander J ZoroufyGary K SchwartzLauren J RogakGita ThanarajasingamEthan BaschAmylou C Dueck

Published in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2021)

For between-arm comparisons, mixed modeling and multiple imputation are informative techniques for handling missing PRO-CTCAE scores. CTCAE grades do not provide added benefit for informing missing PRO-CTCAE scores. ClinicalTrials.gov Identifiers: NCT02066181 (Alliance A091105); NCT01522443 (COMET-2).

Keyphrases

patient reported outcomes
anti inflammatory
electronic health record
big data
machine learning
artificial intelligence
deep learning