Ciprofol alleviates remifentanil-induced hyperalgesia by regulating α2GABAARs, NR2B, and P-CaMKIIα levels in the spinal cord and hippocampus.
Yang YangChao YangYujie ShiChengyuan TangHanyu WangMengyuan TanRuyi XingChen GaoMin ZhangYanhu XiePublished in: The Journal of pharmacy and pharmacology (2024)
Ciprofol alleviates RIH effectively, and the anti-hyperalgesic mechanisms may involve increasing α2GABAAR levels and decreasing NR2B and P-CaMKIIα levels in the spinal cord and hippocampus.