Coculture of adipose-derived mesenchymal stem cells/macrophages on decellularized placental sponge promotes differentiation into the osteogenic lineage.
Zahra KhosrowpourSeyed Mahmoud HashemiSamira Mohammadi-YeganehMehdi MoghtadaeiPeiman Brouki MilanLorenzo MoroniSubhas C KunduMazaher GholipourmalekabadiPublished in: Artificial organs (2022)
Our findings suggest the decellularized placental sponge as an excellent bone substitute providing a naturally derived matrix substrate with biostructure close to the natural bone that guided differentiation of stem cells toward bone cells and a promising coculture substrate for crosstalk of macrophage and mesenchymal stem cells in vitro.
Keyphrases
- mesenchymal stem cells
- stem cells
- bone mineral density
- soft tissue
- adipose tissue
- bone loss
- extracellular matrix
- induced apoptosis
- bone marrow
- bone regeneration
- umbilical cord
- postmenopausal women
- cell therapy
- insulin resistance
- metabolic syndrome
- cell cycle arrest
- type diabetes
- single cell
- cell proliferation
- signaling pathway