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Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation.

Yangjun ChenDiana Diaz-DussanDi WuWenda WangYi-Yang PengAnika Benozir AshaDennis G HallKazuhiko IshiharaRavin Narain
Published in: ACS macro letters (2018)
Boronic ester, one typical example of dynamic covalent bonds, has presented great potential to prepare self-healing hydrogels. However, most of currently reported hydrogels based on boronic esters are formed at pH > 8, which impeded their further use in physiological conditions. In this study, we designed two kinds of zwitterionic copolymers with benzoxaborole and catechol pendant groups, respectively. Owing to the lower p K a value of benzoxaborole (7.2), gelation can happen easily at pH 7.4 PBS after mixing these two copolymers due to efficient formation of benzoxaborole-catechol complexations. The resulting hydrogels exhibited excellent self-healing property as well as dual pH/sugar responsiveness due to the dynamic nature of boronic ester. Moreover, benefiting from the cell membrane bioinspired 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymeric matrix, the hydrogel was further investigated for 3D cell encapsulation. The combination of biocompatible zwitterionic polymers with dynamic benzoxaborole-catechol complexation makes the hydrogels a promising platform for diverse potential bioapplications like drug delivery and tissue engineering.
Keyphrases
  • wound healing
  • drug delivery
  • tissue engineering
  • drug release
  • single cell
  • cell therapy
  • cancer therapy
  • human health
  • risk assessment
  • hyaluronic acid
  • ionic liquid
  • bone marrow
  • extracellular matrix