Influence of FPGS, ABCC4, SLC29A1, and MTHFR genes on the pharmacogenomics of fluoropyrimidines in patients with gastrointestinal cancer from the Brazilian Amazon.

Marianne Rodrigues Fernandes Juliana Carla Gomes Rodrigues Elizabeth Ayres Fragoso Dobbin Lucas Favacho Pastana Danielle Feio da Costa Williams Fernandes Barra Antônio André Conde Modesto Paula Baraúna de Assumpção Artur Luiz da Costa da Silva Sidney Emanuel Batista Dos Santos Rommel Mario Rodríguez Burbano Paulo Pimentel de Assumpção Ney Pereira Carneiro Dos Santos

Published in: Cancer chemotherapy and pharmacology (2021)

Four polymorphisms of the ABCC4, FPGS, SLC29A1, and MTHFR genes are likely to be potential predictive biomarkers for precision medicine in fluoropyrimidine-based treatments in the population of the Brazilian Amazon, which is constituted by a unique genetic background.

Keyphrases

genome wide
papillary thyroid
genome wide identification
dna methylation
squamous cell
emergency department
gene expression
human health
risk assessment
young adults
adverse drug
climate change
childhood cancer