Internal modifications in the CENP-A nucleosome modulate centromeric dynamics.

Minh BuiMary PitmanArthur NuccioSerene RoquePaul Gregory Donlin-AspAleksandra Nita-LazarGaregin A PapoianYamini Dalal

Published in: Epigenetics & chromatin (2017)

Taken together, our data suggest that cyclical modifications within the CENP-A nucleosome contribute to the binding of key kinetochore proteins, the integrity of mitosis, and centromeric replication. These data support the paradigm that modifications in histone variants can influence key biological processes.

Keyphrases

electronic health record
big data
dna methylation
copy number
machine learning
binding protein
dna binding